可药性
化学
鉴定(生物学)
计算生物学
药物发现
功能(生物学)
S-亚硝基化
蛋白质功能
半胱氨酸
生物化学
小分子
药物开发
药品
药理学
细胞生物学
酶
生物
基因
植物
作者
Hui Ye,Jianbing Wu,Zhuangzhuang Liang,Yihua Zhang,Zhangjian Huang
标识
DOI:10.1021/acs.jmedchem.1c02194
摘要
Protein S-nitrosation (SNO), a posttranslational modification (PTM) of cysteine (Cys) residues elicited by nitric oxide (NO), regulates a wide range of protein functions. As a crucial form of redox-based signaling by NO, SNO contributes significantly to the modulation of physiological functions, and SNO imbalance is closely linked to pathophysiological processes. Site-specific identification of the SNO protein is critical for understanding the underlying molecular mechanisms of protein function regulation. Although careful verification is needed, SNO modification data containing numerous functional proteins are a potential research direction for druggable target identification and drug discovery. Undoubtedly, SNO-related research is meaningful not only for the development of NO donor drugs but also for classic target-based drug design. Herein, we provide a comprehensive summary of SNO, including its origin and transport, identification, function, and potential contribution to drug discovery. Importantly, we propose new views to develop novel therapies based on potential protein SNO-sourced targets.
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