乙二醇
生物相容性
体内
聚合物
化学
PEG比率
药物输送
材料科学
生物医学工程
医学
纳米技术
有机化学
财务
生物
生物技术
经济
作者
Sennan Xu,Lingjie Ke,Sichen Zhao,Zhiguo Li,Yang Xiao,Yun Wu,Jie Ren,Yan Qiu
出处
期刊:Pharmaceutics
[MDPI AG]
日期:2021-12-27
卷期号:14 (1): 50-50
被引量:9
标识
DOI:10.3390/pharmaceutics14010050
摘要
The spread of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the coronavirus disease 2019 (COVID-19) outbreak beginning in March 2020. Currently, there is a lack of suitable dose formulations that interrupt novel coronavirus transmission via corneal and conjunctival routes. In the present study, we developed and evaluated a thermosensitive gelling system based on a selenium-containing polymer for topical ocular continuous drug release. In detail, di-(1-hydroxylundecyl) selenide (DHSe), poly(ethylene glycol) (PEG), and poly(propylene glycol) (PPG) were polymerized to form poly(DHSe/PEG/PPG urethane). The polymer was used to carry poorly water-soluble remdesivir (RDV) at room temperature to form the final thermosensitive in situ gel, which exhibited a typical sol-gel transition at 35 °C. The formed polymer was further characterized by rheology, thermology, and scanning electron microscopy. In vitro release studies and in vivo retention and penetration tests indicated that the thermogel provided the prolonged release of RDV. The RDV-loaded in situ gel was proven to be non-biotoxic against human corneal epithelial cells, with good ocular tolerance and biocompatibility in rabbit eyes.
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