全合成
生物发生
天然产物
组合化学
模块化设计
合成生物学
打
化学
计算机科学
计算生物学
立体化学
生物
生物化学
程序设计语言
数学
基因
算术
作者
Kyan A. D’Angelo,Carly K. Schissel,Bradley L. Pentelute,Mohammad Movassaghi
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2022-02-25
卷期号:375 (6583): 894-899
被引量:9
标识
DOI:10.1126/science.abm6509
摘要
The natural product himastatin has an unusual homodimeric structure that presents a substantial synthetic challenge. We report the concise total synthesis of himastatin from readily accessible precursors, incorporating a final-stage dimerization strategy that was inspired by a detailed consideration of the compound's biogenesis. Combining this approach with a modular synthesis enabled expedient access to more than a dozen designed derivatives of himastatin, including synthetic probes that provide insight into its antibiotic activity.
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