纳米医学
细胞凋亡
体内
癌症研究
癌细胞
声动力疗法
癌症
内化
联合疗法
化学
药理学
癌症治疗
细胞
医学
纳米技术
生物
材料科学
生物化学
纳米颗粒
内科学
生物技术
作者
Rongrong Zheng,Yibin Liu,Baixue Yu,Lin‐Ping Zhao,Yang Ni,Ali Chen,Lin Xu,Hong Cheng,Xueyan Jiang,Shiying Li
标识
DOI:10.1016/j.jcis.2022.04.090
摘要
Although photodynamic therapy (PDT) has been well-known as a promising anti-tumor treatment, its limited therapeutic efficiency remains to be a large challenge. In this study, a carrier free nanomedicine (designated as PyroMor) is developed to greatly initiate cell apoptosis and paraptosis for synergistic cancer therapy. Pyropheophorbide-a (Pyro) and morusin (Mor) are capable of self-assembling into PyroMor, which has been testified to have superiority of improved stability, cellular internalization, and biocompatibility. Because of efficient cellular uptake behavior, PyroMor could induce cellular paraptosis by Mor-caused vacuolation in mitochondria, ER and cytoplasm, contributing to improving the PDT efficacy of Pyro. Therefore, self-delivery PyroMor is able to accomplish synergistic anti-tumor effect via stimulation of cell apoptosis as well as paraptosis. In addition, in vivo studies also clarify that PyroMor presents passive tumor targeting delivery, leading to robust repressive effect on tumor proliferation with negligible systemic toxicity. This strategy of combined cancer therapy by initiating both cell apoptosis and paraptosis extremely benefits to the development of precise and effective cancer therapy in clinic.
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