Prospective multicentre single-arm study of an interatrial shunt in heart failure with reduced ejection fraction (SUSTAIN-HF): 1-year clinical and haemodynamic outcomes

In this prospective cohort study of symptomatic HFrEF patients, treatment with the D-Shant atrial shunt device was associated with significant improvements in functional capacity, quality of life and rates of heart failure hospitalisation at 1 year. The single-arm design precludes definitive conclusions on treatment efficacy, underscoring the need for randomised, sham-controlled trials.