病毒学
病毒
抗原
效价
抗体
免疫
中和抗体
生物
抗体反应
免疫学
作者
Ki‐Back Chu,Su‐Hwa Lee,Min-Ju Kim,Ahra Kim,Eun‐Kyung Moon,Fu‐Shi Quan
出处
期刊:Nanomedicine
日期:2022-07-01
卷期号:17 (17): 1159-1171
被引量:6
标识
DOI:10.2217/nnm-2022-0082
摘要
Aims: The purpose of this study was to assess the protective efficacy of virus-like particles (VLPs) co-expressing the pre-fusogenic (PreF) and G protein with tandem repeats (Gt) antigens of respiratory syncytial virus (RSV) in mice. Materials & methods: VLP constructs expressing PreF, Gt or both were used to immunize mice, and the protective efficacies were evaluated using antibody responses, neutralizing antibody titers, T-cell responses, histopathological assessment and plaque assay. Results: PreF+Gt VLP immunization elicited strong RSV-specific antibody responses and pulmonary T-cell responses that contributed to lessening virus titer and inflammation. Conclusion: Our findings suggest that coexpressing PreF and Gt antigens elicits better protection than either one alone. This combinatorial approach could assist in future RSV vaccine development.
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