Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

Taurine, an amino‐sulfonic acid mainly sourced from food, suppresses blood glucose by stimulating insulin secretion from pancreatic β‐cells. However, its relationship with glucagon‐like peptide‐1 (GLP‐1) secretion from enteroendocrine L cells is unclear. This study aimed to determine the role of taurine in GLP‐1 secretion from L cells. Taurine administration promoted GLP‐1 secretion in enteroendocrine L cell line GLUTag cells and increased plasma GLP‐1 in mice. Taurine uptake via the taurine transporter increased cytosolic ATP levels, resulting in higher intracellular Ca 2+ concentrations and enhanced GLP‐1 secretion through ATP‐sensitive K + channel closure. These findings may help identify new therapeutic targets for obesity and diet‐related disease prevention.