免疫疗法
癌症免疫疗法
癌症研究
免疫系统
黑色素瘤
自愈水凝胶
吉西他滨
抗体
CD8型
弹性蛋白
癌症
医学
PD-L1
免疫学
材料科学
内科学
病理
高分子化学
作者
Jinguang Chen,Ming Cui,Lianping He,Yeteng Mu,Nannan Hu,Xingang Guan
摘要
Immune checkpoint inhibitors (ICIs) have effectively eradicated advanced tumors by inducing durable and systematic antitumor immune responses. However, when used as a standalone treatment, ICIs typically exhibit a low response rate in many cancers. In this study, we engineered an in situ-formed gel depot using elastin-like polypeptides (ELPs) to efficiently deliver PD-L1 antibodies (aPD-L1) and gemcitabine (GEM) for enhanced immunotherapy in melanoma. Sustainably released chemotherapeutics from gel depots could kill melanoma cells and promote PD-L1 upregulation in tumor cells. Moreover, aPD-L1/GEM-encapsulated ELP hydrogel promoted a 3.0-fold increase of tumor-infiltrated CD8+ T cells and 60% Tregs depletion compared with PBS group, eliciting a robust antitumor immune response for immunotherapy in melanoma mouse models. This research highlights the promising potential of ELP-based hydrogels in delivering ICIs and chemotherapeutic agents for potentiated cancer immunotherapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI