生物
肠道菌群
机制(生物学)
微生物群
人类健康
肠道微生物群
功能(生物学)
人体微生物群
免疫系统
计算生物学
人类疾病
疾病
蛋白质功能
生物信息学
免疫学
进化生物学
遗传学
基因
医学
环境卫生
认识论
哲学
病理
作者
Daniel Balint,Ilana Brito
标识
DOI:10.1016/j.tim.2023.09.009
摘要
The human gut microbiome is associated with a wide range of diseases; yet, the mechanisms these microbes use to influence human health are not fully understood. Protein-protein interactions (PPIs) are increasingly identified as a potential mechanism by which gut microbiota influence their human hosts. Similar to some PPIs observed in pathogens, many disease-relevant human-gut bacterial PPIs function by interacting with components of the immune system or the gut barrier. Here, we highlight recent advances in these two areas. It is our opinion that there is a vastly unexplored network of human-gut bacterial PPIs that contribute to the prevention or pathogenesis of various diseases and that future research is warranted to expand PPI discovery.
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