Biswulfenioidins A–E, dioxygen-bridged abietane-type diterpenoid dimers with anti-Zika virus potential from Orthosiphon wulfenioides

Six dioxygen-bridged abietane-type diterpenoid dimers with unprecedented angular fused and rare parallel fused structures were isolated from Orthosiphon wulfenioides . Notably, compounds 5 and 6 showed potent activity against ZIKV by inhibiting the expression of the E and NS5 protein.