Effect Of Acetaldehyde On Aggregation Of Neuronal Tau

Abstract: Acetaldehyde at a low concentration (0.25%) induces recombinant tau polymeriz.ation distinguishably without using chemic.al cross-linker disuccinimidyl su (DSS). The aggregation of the hyperphosphorylated tau occurs in the solution of acetaldehyde at 0.05%. It appears that formation of neurofibrillary tangles in alcoholics may be correlated to acetaldehyde besides alcoho and the abnormal tau phosphorylation may accelerate acetaldehyde-induced tau polymeriz.ation.