Essential proteins identification based on weak consensus model and neighborhood aggregation centrality

Essential proteins play an essential role in cell survival and replication. Currently, more and more computational methods are developed to identify essential proteins, which overcome the time-consuming, costly and inefficient shortcomings with biological experimental methods. In order to improve the recognition rate, some new methods by fusing multiple features are developed, but they seldom consider the connection among features. After analyzing a large number of methods based on multi-feature fusion, a weak consensus model to fuse features is proposed in this paper. Then, this paper uses the weak consensus model to fuse protein-protein interaction network, gene expression data, and orthologous data, thus proposing a new method, WOL. Then experiments are performed on one S.cerevisiae dataset. The results show that compared with WDC, PeC, ION, JDC, NCCO and E_POC, WOL has a higher recognition rate.