Enantioanalysis of Cysteine Using an Enantioselective Stochastic Platform: A Key Factor on Early Diagnosis of Breast Cancer

Abstract Proteomics and metabolomics have identified novel biomarkers, such as enantiomers of amino acids, that can be used for the early detection of cancer. This paper proposed a 3D enantioselective stochastic platform that contains a mixture of powder (diamond powder and TiO2) modified with calix [6] arene and has been used for the enantioanalysis of L- and D-Cysteine in biological samples. The results demonstrated an extended linear concentration range (up to 10-18mol L-1) and sensitivities of 1.00×107 s mol L-1 magnitude order. The recoveries of the enantiomers in biological samples were higher than 98.00%.