肌萎缩
炎症体
炎症
骨骼肌
医学
肌球蛋白
衰老
内科学
先天免疫系统
免疫学
生物
免疫系统
细胞生物学
作者
Eduardo Antuña,Yaiza Potes,Francisco Javier Baena-Huerta,Cristina Cachán-Vega,Nerea Menéndez-Coto,E Álvarez Darriba,Marta Fernández-Fernández,Natalie Burgos Bencosme,Manuel Bermúdez,Eva María López Álvarez,José Gutiérrez-Rodríguez,José Antonio Boga,Beatriz Caballero,Ignacio Vega‐Naredo,Ana Coto‐Montes,Claudia García-González
摘要
Sarcopenia, a complex and debilitating condition characterized by progressive deterioration of skeletal muscle, is the primary cause of age-associated disability and significantly impacts healthspan in elderly patients. Despite its prevalence among the aging population, the underlying molecular mechanisms are still under investigation. The NLRP3 inflammasome is crucial in the innate immune response and has a significant impact on diseases related to inflammation and aging. Here, we investigated the expression of the NLRP3 inflammasome pathway and pro-inflammatory cytokines in skeletal muscle and peripheral blood of dependent and independent patients who underwent hip surgery. Patients were categorized into independent and dependent individuals based on their Barthel Index. The expression of NLRP3 inflammasome components was significantly upregulated in sarcopenic muscle from dependent patients, accompanied by higher levels of Caspase-1, IL-1β and IL-6. Among older dependent individuals with sarcopenia, there was a significant increase in the MYH3/MYH2 ratio, indicating a transcriptional shift in expression from mature to developmental myosin isoforms. Creatine kinase levels and senescence markers were also higher in dependent patients, altogether resembling dystrophic diseases and indicating muscle degeneration. In summary, we present evidence for the involvement of the NLRP3/ASC/NEK7/Caspase-1 inflammasome pathway with activation of pro-inflammatory SASP in the outcome of sarcopenia in the elderly.
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