药物发现
药品
抗体
小分子
药学
计算生物学
药理学
化学
医学
生物
免疫学
生物化学
作者
Haochun Jin,Dongliang Cui,Yun Fan,Guodong Li,Zhangfeng Zhong,Yitao Wang
标识
DOI:10.1016/j.drudis.2024.103885
摘要
Bioaffinity drug screening strategies have gained popularity in preclinical and clinical drug discovery for natural products, small molecules and antibodies owing to their superior selectivity, the large number of compounds to be screened and their ability to minimize the time and expenses of the drug discovery process. This paper provides a systematic summary of the principles of commonly used bioaffinity-based screening methods, elaborates on the success of bioaffinity in clinical drug development and summarizes the active compounds, preclinical drugs and marketed drugs obtained through affinity screening methods. Owing to the high demand for new drugs, bioaffinity-guided screening techniques will play a greater part in clinical drug development.
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