卵母细胞
排卵
细胞生物学
信号转导
内分泌学
战斗或逃跑反应
内科学
生物
化学
医学
激素
基因
生物化学
胚胎
作者
Lydia Grmai,Manuel Michaca,Emily Lackner,Narayanan Nampoothiri V.P.,Deepika Vasudevan
出处
期刊:Cell Reports
[Elsevier]
日期:2024-03-01
卷期号:43 (3): 113863-113863
标识
DOI:10.1016/j.celrep.2024.113863
摘要
Summary
Reproduction is an energy-intensive process requiring systemic coordination. However, the inter-organ signaling mechanisms that relay nutrient status to modulate reproductive output are poorly understood. Here, we use Drosophila melanogaster as a model to establish the integrated stress response (ISR) transcription factor, Atf4, as a fat tissue metabolic sensor that instructs oogenesis. We demonstrate that Atf4 regulates lipase activity to mediate yolk lipoprotein synthesis in the fat body. Depletion of Atf4 in the fat body also blunts oogenesis recovery after amino acid deprivation and re-feeding, suggestive of a nutrient-sensing role for Atf4. We also discovered that Atf4 promotes secretion of a fat-body-derived neuropeptide, CNMamide, which modulates neural circuits that promote egg-laying behavior (ovulation). Thus, we posit that ISR signaling in fat tissue acts as a "metabolic sensor" that instructs female reproduction—directly by impacting yolk lipoprotein production and follicle maturation and systemically by regulating ovulation.
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