Sprayable Hydrogel Sealant for Gastrointestinal Wound Shielding

Abstract Naturally occurring internal bleeding, such as in stomach ulcers, and complications following interventions, such as polyp resection post‐colonoscopy, may result in delayed (5–7 days) post‐operative adverse events—such as bleeding, intestinal wall perforation, and leakage. Current solutions for controlling intra‐ and post‐procedural complications are limited in effectiveness. Hemostatic powders only provide a temporary solution due to their short‐term adhesion to GI mucosal tissues (less than 48 h). In this study, a sprayable adhesive hydrogel for facile application and sustained adhesion to GI lesions is developed using clinically available endoscopes. Upon spraying, the biomaterial (based on polyethyleneimine‐modified Pluronic micelles precursor and oxidized dextran) instantly gels upon contact with the tissue, forming an adhesive shield. In vitro and in vivo studies in guinea pigs, rabbits, and pig models confirm the safety and efficacy of this biomaterial in colonic and acidic stomach lesions. The authors' findings highlight that this family of hydrogels ensures prolonged tissue protection (3–7 days), facilitates wound healing, and minimizes the risk of delayed complications. Overall, this technology offers a readily adoptable approach for gastrointestinal wound management.