分解代谢
新陈代谢
蛋白质代谢
脂肪酸代谢
尿素
化学
氨基酸
蛋白质生物合成
蛋白质降解
蛋白激酶A
脂肪酸结合蛋白
生物化学
激酶
基因
作者
Gang Li,Jiao Zhang,Lin He,Lanlan Li,Yuxin Song,Wenjun Xiao,Zhihua Gong
标识
DOI:10.1002/mnfr.202200198
摘要
Scope l-Theanine (LTA) is a non-protein amino acid that contributes to the flavor of tea and can regulate protein metabolism of healthy organisms. However, it is unknown whether it regulates protein metabolism in individuals on high-protein diets (HPDs). Methods and results Here, Sprague–Dawley rats are fed HPDs with different protein supply ratios and administered a diverse dose of LTA for 40 days. Results show that HPDs with an energy supply ratio from protein >40% impair the liver and kidneys, elevate serum ammonia and urea nitrogen, induce amino acid (AA) catabolism, and promote fatty acid (FA) synthesis via FA-binding protein 5 (Fabp5) and acetyl-CoA carboxylase 1 (ACC1). LTA intervention alleviates HPD-induced hepatic and renal injury and improves serum biochemical indices. It increases hepatic free AA content and inhibits FA synthesis by downregulating Fabp5 and ACC1. It promotes protein synthesis by acting on the mammalian target of rapamycin (mTOR) pathway, thereby alleviating HPD-induced metabolic disorders. Conclusions This study demonstrates that LTA mitigates kidney and liver damage induced by long-term excess HPDs by regulating protein metabolism.
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