cccDNA
乙型肝炎病毒
病毒学
肝细胞癌
微小染色体
病毒复制
环状DNA
生物
医学
病毒
免疫学
基因
癌症研究
乙型肝炎表面抗原
遗传学
基因组
作者
María del Carmen Jiménez Martínez,Elena M. Smekalova,Emmanuel Combe,Francine M. Gregoire,Fabien Zoulim,Barbara Testoni
出处
期刊:Viruses
[MDPI AG]
日期:2022-11-28
卷期号:14 (12): 2654-2654
被引量:6
摘要
Hepatitis B virus (HBV) remains a significant cause of mortality and morbidity worldwide, since chronic HBV infection is associated with elevated risk of cirrhosis and hepatocellular carcinoma. Current licensed therapies against HBV efficiently suppress viral replication; however, they do not have significant effects on the intrahepatic covalently closed circular DNA (cccDNA) of the viral minichromosome responsible for viral persistence. Thus, life-long treatment is required to avoid viral rebound. There is a significant need for novel therapies that can reduce, silence or eradicate cccDNA, thus preventing HBV reemergence after treatment withdrawal. In this review, we discuss the latest developments and applications of gene editing and related approaches for directly targeting HBV DNA and, more specifically, cccDNA in infected hepatocytes.
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