非酒精性脂肪肝
医学
时间轴
疾病
脂肪肝
透视图(图形)
重症监护医学
肝病学
人口
肝病
梅德林
生物信息学
内科学
环境卫生
生物
计算机科学
人工智能
考古
历史
生物化学
标识
DOI:10.1038/s41575-019-0144-8
摘要
Nonalcoholic fatty liver disease (NAFLD) was first described as a distinct clinical entity four decades ago. However, the condition has become the centre of attention within hepatology owing to its high prevalence and growing contribution to the burden of end-stage liver disease in the general population. This Perspective provides an overview on the development of knowledge related to NAFLD with a focus on landmark findings that have influenced current paradigms and key knowledge gaps that need to be filled to make progress. Specifically, a timeline of scientific discovery of both basic disease mechanisms (with a focus on human data) and the evolution of knowledge about the clinical course of the disease is provided and related to current approaches to treat and eventually prevent NAFLD.
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