Effectiveness of a Serogroup B and C Meningococcal Vaccine Developed in Cuba.

异源的 流行性脑脊髓膜炎 接种疫苗 脑膜炎奈瑟菌 血清学 病毒学 医学 脑膜炎球菌疫苗 爆发 效价 微生物学 免疫学 生物 抗体 免疫 病毒 细菌 基因 生物化学 遗传学
作者
Rolando Ochoa-Azze,Luis Guillermo García-Imía,Vicente Vérez-Bencomo
出处
期刊:MEDICC Review [Medical Education Cooperation with Cuba]
卷期号:20 (3): 22-29 被引量:8
标识
DOI:10.1590/medicc.2018.20030008
摘要

INTRODUCTION Serogroup B meningococcal outer membrane vesicle vaccines have been effective against vaccine-type strains, but their effectiveness against heterologous strains has been controversial. The Cuban VA-MENGOC-BC vaccine is of this type, but also includes meningococcus C capsular polysaccharide. OBJECTIVES Assess the effectiveness of VA-MENGOC-BC in reducing meningococcal disease caused by homologous or heterologous serogroup B strains and its serological effectiveness against meningococcus C. METHODS A review of studies of VA-MENGOC-BC's application in Cuba, Brazil, Uruguay and Colombia was carried out to examine the vaccine's effectiveness in reducing meningococcal disease during serogroup B outbreaks. Serological effectiveness against serogroup C determined in these studies (indicated by bactericidal antibody titers before and after vaccination) was also analyzed. RESULTS VA-MENGOC-BC's effectiveness against homologous serogroup B strains has consistently been greater than 80% in all age groups. Effectiveness in heterologous contexts was also above 80% in individuals aged >4 years. Lower effectiveness in heterologous contexts was found in Brazilian children aged 50%. Effectiveness increased when assessed based on mortality rates, as well as in cases of clinically severe meningococcal disease. The carrier-state pattern was modified after vaccination with reduction of hypervirulent lineages. Some 60% of infants (aged <1 year) attained protective bactericidal antibody titers against serogroup C. Higher protection rates were achieved in older children. CONCLUSIONS In addition to prevention of meningococcal disease caused by homologous serogroup B strains, VA-MENGOC-BC should be considered for heterologous contexts. It is protective against serogroup C in all age groups. KEYWORDS Neisseria meningitidis, meningococcal disease, meningococcal vaccines, serogroup B meningococcus, serogroup C meningococcus, immunogenicity, bacterial outer membrane proteins, heterologous effects of vaccines, acellular vaccines, Cuba.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
王子完成签到,获得积分10
1秒前
张晓林完成签到,获得积分20
2秒前
NexusExplorer应助晓晓马儿采纳,获得10
4秒前
Eureka完成签到,获得积分10
5秒前
5秒前
Owen应助小叶不吃香菜采纳,获得10
6秒前
顾矜应助深秋远塞采纳,获得10
7秒前
amy发布了新的文献求助10
9秒前
山色青发布了新的文献求助10
9秒前
老程完成签到,获得积分10
9秒前
CipherSage应助Sia采纳,获得10
10秒前
FTN发布了新的文献求助30
11秒前
choi发布了新的文献求助10
12秒前
华仔应助Tian采纳,获得10
13秒前
贤惠的饼干完成签到,获得积分10
14秒前
Jadie完成签到,获得积分10
14秒前
张文乐完成签到,获得积分10
14秒前
14秒前
14秒前
wangfuhang完成签到,获得积分10
15秒前
AAAAOK发布了新的文献求助10
15秒前
无所谓发布了新的文献求助10
16秒前
16秒前
认真芷容完成签到,获得积分10
16秒前
18秒前
aaa八角锋哥完成签到,获得积分10
19秒前
胡添傲完成签到,获得积分20
19秒前
科研通AI2S应助菲菲采纳,获得10
19秒前
科研通AI6.1应助应语采纳,获得30
20秒前
深秋远塞发布了新的文献求助10
21秒前
英俊的铭应助Alces采纳,获得10
21秒前
711完成签到,获得积分10
22秒前
Lcooper完成签到,获得积分10
22秒前
SciGPT应助choi采纳,获得10
24秒前
英俊的铭应助科研通管家采纳,获得10
24秒前
24秒前
大个应助科研通管家采纳,获得10
24秒前
无花果应助科研通管家采纳,获得10
24秒前
25秒前
高分求助中
The Graphene Handbook (2019 Edition) 800
Signals, Systems, and Signal Processing 610
IEST-RP-CC018: Cleanroom Cleaning and Sanitization: Operating and Monitoring Procedures 600
Fundamentals of Pharmaceutical and Biologics Regulations: A Global Perspective, Second Edition 600
久松真一著作集〈第5巻〉禅と芸術 500
Fundamentals of Modern Mathematics: A Practical Review (Dover Books on Mathematics) 500
Cold War Transcended: Australia's China Policy, 1949-1990 470
热门求助领域 (近24小时)
化学 材料科学 医学 生物 纳米技术 工程类 有机化学 化学工程 生物化学 计算机科学 物理 内科学 复合材料 催化作用 物理化学 光电子学 电极 细胞生物学 基因 无机化学
热门帖子
关注 科研通微信公众号,转发送积分 6601390
求助须知:如何正确求助?哪些是违规求助? 8370015
关于积分的说明 17914481
捐赠科研通 5757195
什么是DOI,文献DOI怎么找? 2954750
邀请新用户注册赠送积分活动 1929836
关于科研通互助平台的介绍 1825887