烯丙基重排
对映选择合成
羟基化
亲核细胞
化学
有机催化
催化作用
路易斯酸
有机化学
基础(拓扑)
立体化学
药物化学
数学
数学分析
酶
作者
Bo Zhu,Lin Yang,Yuanhang Pan,Richmond Lee,Hongjun Liu,Zhiqiang Han,Kuo‐Wei Huang,Choon‐Hong Tan,Zhiyong Jiang
摘要
A Lewis base catalyzed allylic hydroxylation of Morita–Baylis–Hillman (MBH) carbonates has been developed. Various chiral MBH alcohols can be synthesized in high yields (up to 99%) and excellent enantioselectivities (up to 94% ee). This is the first report using water as a nucleophile in asymmetric organocatalysis. The nucleophilic role of water has been verified using 18O-labeling experiments.
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