恶病质
浪费的
癌症
骨骼肌
生物
生物标志物
腰椎
定量计算机断层扫描
肌萎缩
计算机断层摄影术
放射科
内科学
医学
解剖
骨质疏松症
内分泌学
骨密度
生物化学
作者
Seyyed Mohammad Reza Kazemi‐Bajestani,Vera C. Mazurak,Vickie E. Baracos
标识
DOI:10.1016/j.semcdb.2015.09.001
摘要
Cancer cachexia (i.e., skeletal muscle wasting with or without fat loss) relates to several adverse outcomes. Computed tomography (CT) cross-sectional images serve as an efficient biomarker for assessment of cachexia in cancer patients. We systematically reviewed literature reporting quantitative evaluation of the cross sectional area of the main tissues implicated in cancer cachexia, muscle and visceral, subcutaneous and inter-muscular fat in CT scans at the 3rd lumbar vertebra. Our main goal was to summarize CT-defined variation of muscle and fat and the relationship between these features and cancer outcomes such as chemotherapy toxicity, post-surgery complications and survival.
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