Investigation of the Inhibition of IRE-1/XBP-1 Pathway in the Multiple Nematicidal Mechanisms of Isobavachalcone against Meloidogyne incognita

. Moreover, molecular docking and dynamics simulations confirmed that IBC stably bound to the ATP-binding pocket of IRE-1. Importantly, the inhibition of IRE-1/XBP-1 pathway was revealed for the first time in nematode lethality. These findings indicate its potential for development as a novel nematicide.