免疫原性
纳米载体
生物相容性
微载波
多糖
纳米技术
药物输送
天然聚合物
化学
基因传递
材料科学
聚合物
免疫系统
生物
遗传增强
生物化学
免疫学
细胞
有机化学
基因
作者
Kaili Wang,Mingqi Liu,Ran Mo
标识
DOI:10.1016/j.medidd.2020.100031
摘要
Micro- and nanotechnology-based carriers for protein delivery are continuously being developed and refined. Their advantages for protein therapeutics include enhanced bioavailability, stability, and permeability and reduced immunogenicity. Natural polysaccharides have aroused widespread interest in protein delivery systems due to their superior biocompatibility, low immunogenicity, and abundance. In this review, we survey recent advances in microcarriers and nanocarriers using biomaterials and formulations derived from natural polysaccharides. Potential applications and challenges for future development are also discussed.
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