脂质体
拉米夫定
诱捕
小泡
析因实验
分散性
色谱法
体内
材料科学
化学
药理学
纳米技术
生物化学
医学
外科
病毒学
生物
膜
病毒
数学
生物技术
乙型肝炎病毒
统计
高分子化学
作者
Mangesh D. Godbole,Prafulla Sabale,Vijay B. Mathur
标识
DOI:10.1080/02652048.2020.1778806
摘要
Aim: This work aimed to encapsulate lamivudine in liposomes for targeted delivery to HIV reservoirs and thereby reduce its side effects.Methods: The lamivudine liposomes were prepared by thin film hydration method using 32 factorial design and characterised for vesicle size, % drug entrapment efficiency, polydispersity index etc. Optimisation by graphical and numerical methods was carried out by fixing minimum and maximum limits for each response. In vivo plasma and tissue distribution of plain lamivudine and lamivudine encapsulated optimised liposomes were compared in rats.Results: The optimised liposomes displayed vesicle size 276.20 ± 13.36 nm, percent entrapment 60.20 ± 2.86% and PDI 0.291 ± 0.053. Compared to plain lamivudine, the liposomes were rapidly cleared from the plasma and displayed 10.97 ± 0.72 and 1.38 ± 0.52 fold accumulation in liver and spleen tissues respectively.Conclusions: Lamivudine encapsulated in liposomes remains in the body for a longer period of time with well distribution in tissues.
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