C-Reactive Protein in the Prediction of Localization of Gastrointestinal Perforation

<b><i>Aim:</i></b> Information regarding the localization of the anatomic site of gastrointestinal (GI) tract perforation is essential for the following surgical procedure. The purpose of this study was to evaluate the significance of C-reactive protein (CRP) and other circulating markers for the prediction of the localization of intra-abdominal hollow organ perforation. <b><i>Methods:</i></b> Measurements of serum markers were analyzed in 423 patients with GI tract perforations, who were divided according to the intraoperative diagnosis into colorectal and upper GI tract perforation groups. <b><i>Results:</i></b> Levels of CRP were higher in patients with colorectal perforations than in upper GI tract perforations (<i>p</i> &#x3c; 0.001). Moreover, high levels of CRP were associated with increased mortality of patients with hollow organ perforations (<i>p</i> = 0.009), which was largely driven by the subset of patients with perforations of the upper GI tract (<i>p</i> = 0.001). <b><i>Conclusion:</i></b> Increased CRP levels predict worse clinical outcome in patients with intra-abdominal hollow organ perforations and are associated with perforations in the colorectal tract. Thus, CRP might be a useful marker for preoperative risk stratification and prediction of the localization of the perforation site.