Rationale and Background on Tumor-Treating Fields for Glioblastoma

Glioblastoma (GBM) is a malignancy of the central nervous system. In the 1860s, Rudolf Virchow was the first to provide a pathologic description of glioma cells (DeAngelis & Mellinghoff, 2011). Johnson (1885) published the first attempted resection by A. Hughes Bennett. Bailey and Cushing (1926) provided the first modern pathologic classification of GBM. Modern medicine has evolved to the current standard of care of maximal safe resection followed by concurrent radiochemotherapy and then adjuvant chemotherapy. However, there remains no cure. Following U.S.