类风湿性关节炎
结晶度
生物利用度
聚乙烯醇
材料科学
药品
医学
药理学
体内
纳米技术
内科学
复合材料
生物技术
生物
作者
Cheng Tao,F.D. Li,Zhenzhen Ma,Xiaoming Li,Yali Zhang,Yuan Le,Jie‐Xin Wang,Jinxia Zhao,Chaoyong Liu,Jianjun Zhang
出处
期刊:Small
[Wiley]
日期:2023-11-14
卷期号:20 (13)
被引量:1
标识
DOI:10.1002/smll.202304150
摘要
Rheumatoid arthritis (RA), a systemic autoimmune disease, poses a significant human health threat. Iguratimod (IGUR), a novel disease-modifying antirheumatic drug (DMARD), has attracted great attention for RA treatment. Due to IGUR's hydrophobic nature, there's a pressing need for effective pharmaceutical formulations to enhance bioavailability and therapeutic efficacy. The high-gravity nanoprecipitation technique (HGNPT) emerges as a promising approach for formulating poorly water-soluble drugs. In this study, IGUR nanodrugs (NanoIGUR) are synthesized using HGNPT, with a focus on optimizing various operational parameters. The outcomes revealed that HGNPT enabled the continuous production of NanoIGUR with smaller sizes (ranging from 300 to 1000 nm), more uniform shapes, and reduced crystallinity. In vitro drug release tests demonstrated improved dissolution rates with decreasing particle size and crystallinity. Notably, in vitro and in vivo investigations showcased NanoIGUR's efficacy in inhibiting synovial fibroblast proliferation, migration, and invasion, as well as reducing inflammation in collagen-induced arthritis. This study introduces a promising strategy to enhance and broaden the application of poorly water-soluble drugs.
科研通智能强力驱动
Strongly Powered by AbleSci AI