Multidimensional Research on Hair Loss in Young Chinese Females With Oily Scalps

ABSTRACT Background In recent years, the problem of female alopecia has been increasing and has shown a trend toward youthfulness. However, there are fewer studies on young female alopecia in the existing literature. Aim We aimed to study the possible causes of hair loss in young Chinese females aged 18–35 with oily scalps. Method Scalp physiological parameters were measured by non‐invasive measurement techniques, scalp lipids were measured by UPLC‐MS/MS, scalp microbiota were measured by macro‐genome sequencing, and the results were analyzed in a multidimensional combined analysis. Result The problematic population showed significant differences in several scalp physiological indices, lipid composition, and microbial community structure compared with the normal population, and eight closely related differential lipids, as well as microorganisms with high relative abundance at the phylum and genus levels, were screened. Conclusion Abnormalities in specific lipids and metabolic pathways, as well as microbiological changes, are associated with hair loss and oily scalp problems.