高尿酸血症
重吸收
肾
嘌呤
肠道菌群
医学
失调
内科学
化学
内分泌学
生物化学
生物
尿酸
酶
作者
Ying Wu,Ying Gao,C. Li,Shirui Zhai,Yao Dong,Shanshan Tie,Lina Zhao,Shaobin Gu
出处
期刊:Food & Function
[The Royal Society of Chemistry]
日期:2025-01-01
卷期号:16 (15): 6080-6100
摘要
BC99 reduces serum uric acid and inhibits UA synthesis in hyperuricemic mice by down-regulating reabsorption proteins, URAT1/GLUT9 and up-regulating excretion transporters, ABCG2/OAT1/3 via Nrf2/NLRP3 modulation. It restores gut microbiota balance and corrects purine/pyrimidine metabolism disorders.
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