Array of Manganese-Based Bimetallic Metal–Organic-Framework Nanozymes with Enhanced Oxidase-like Catalytic Activity Can Simultaneously Identify and Measure Antioxidants

, leading to the generation of fingerprint-like spectral color patterns. The pattern recognition chemometrics methods including principal component analysis (PCA) and linear discriminant analysis (LDA) represent well-separated clustering and discrimination of ascorbic acid, dopamine, uric acid, cysteine, glutathione, thiocyanate, tannic acid, and gallic acid. The colorimetric assay provides a wide linear detection range (0.1-75 μM) and detection limits as low as 30 nM. The sensor array successfully discriminated antioxidants of various concentrations, mixtures, and potent interferences. Furthermore, the sensor's applicability in biologically relevant detection was validated in urine and plasma samples. Overall, the MOF-based nanozyme sensor array offers a promising platform for discriminating and determining a wide range of antioxidants with potential applications.