Prognostic models for unplanned intensive care unit readmission risk prediction: A systematic review and meta‐analysis based on HSROC model

Abstract Background Intensive care unit (ICU) readmission is a critical factor in determining discharge timing and transitional care and is predicted by various models using different approaches. A systematic review is needed to assess the performance and applicability of these models. Aim To identify prognostic models for unplanned ICU readmission and compare the performance of machine learning models with scoring systems. Study Design This is a systematic review and meta‐analysis. We searched 11 databases up to August 21, 2024 for cohort studies on ICU readmission prediction models. The Prediction Model Risk of Bias Assessment Tool assessed model applicability and risk of bias, and meta‐analysis was performed using the Hierarchical Summary Receiver Operating Characteristic Curve model in Stata 16.0. Results Of 2150 articles, 67 were included, describing 335 models and 67 scoring systems. Common predictors included mechanical ventilation, age, blood pressure, gender and heart rate. The meta‐analysis of 199 models showed pooled sensitivities of 0.607 for scoring systems and 0.711 for machine learning models, with specificities of 0.699 and 0.899, respectively. Deep learning models had higher sensitivity (0.745) but lower specificity (0.709). All studies had a high risk of bias. Conclusions Machine learning outperformed scoring systems but ignored clinical notes. Including unstructured text could improve predictions. Models need external validation to ensure reliability across institutions. Relevance to Clinical Practice Models for ICU readmission prediction will aid critical care nurses in identifying high‐risk patients and prioritizing post‐ICU care needs. This can support nurse‐led interventions, improve patient safety and optimize resource allocation for transitional care.