Multicomponent Synthesis of 5‐Cyano‐pyrazolo[1,5‐a]pyrimidines Enabled by Aerobic Manganese Catalysis

Advanced Synthesis & CatalysisVolume 365, Issue 6 p. 871-876 Communication Multicomponent Synthesis of 5-Cyano-pyrazolo[1,5-a]pyrimidines Enabled by Aerobic Manganese Catalysis Heng-Tong Qu, Heng-Tong Qu School of Pharmacy, Anhui University of Chinese Medicine, Anhui academy of Chinese medicine, Hefei, 230012 People's Republic of ChinaSearch for more papers by this authorZeng-Hui Wu, Zeng-Hui Wu School of Pharmacy, Anhui University of Chinese Medicine, Anhui academy of Chinese medicine, Hefei, 230012 People's Republic of ChinaSearch for more papers by this authorGuo-Chen Zhong, Guo-Chen Zhong School of Pharmacy, Anhui University of Chinese Medicine, Anhui academy of Chinese medicine, Hefei, 230012 People's Republic of ChinaSearch for more papers by this authorYan-Chun Zhang, Corresponding Author Yan-Chun Zhang [email protected] School of Pharmacy, Anhui University of Chinese Medicine, Anhui academy of Chinese medicine, Hefei, 230012 People's Republic of ChinaSearch for more papers by this authorCheng-Tao Feng, Cheng-Tao Feng School of Pharmacy, Anhui University of Chinese Medicine, Anhui academy of Chinese medicine, Hefei, 230012 People's Republic of ChinaSearch for more papers by this authorKun Xu, Corresponding Author Kun Xu [email protected] orcid.org/0000-0002-0419-8822 Faculty of Environment and Life, Beijing University of Technology, Beijing, 100124 People's Republic of ChinaSearch for more papers by this author Heng-Tong Qu, Heng-Tong Qu School of Pharmacy, Anhui University of Chinese Medicine, Anhui academy of Chinese medicine, Hefei, 230012 People's Republic of ChinaSearch for more papers by this authorZeng-Hui Wu, Zeng-Hui Wu School of Pharmacy, Anhui University of Chinese Medicine, Anhui academy of Chinese medicine, Hefei, 230012 People's Republic of ChinaSearch for more papers by this authorGuo-Chen Zhong, Guo-Chen Zhong School of Pharmacy, Anhui University of Chinese Medicine, Anhui academy of Chinese medicine, Hefei, 230012 People's Republic of ChinaSearch for more papers by this authorYan-Chun Zhang, Corresponding Author Yan-Chun Zhang [email protected] School of Pharmacy, Anhui University of Chinese Medicine, Anhui academy of Chinese medicine, Hefei, 230012 People's Republic of ChinaSearch for more papers by this authorCheng-Tao Feng, Cheng-Tao Feng School of Pharmacy, Anhui University of Chinese Medicine, Anhui academy of Chinese medicine, Hefei, 230012 People's Republic of ChinaSearch for more papers by this authorKun Xu, Corresponding Author Kun Xu [email protected] orcid.org/0000-0002-0419-8822 Faculty of Environment and Life, Beijing University of Technology, Beijing, 100124 People's Republic of ChinaSearch for more papers by this author First published: 27 February 2023 https://doi.org/10.1002/adsc.202201361Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Graphical Abstract An aerobic Mn(III)-catalyzed one-pot three-component synthesis of 5-cyano-pyrazolo[1,5-a]pyrimidines has been described. The synergistic combination of Strecker reaction and oxidatively-induced 6π-azacyclization is the key to the success of this multicomponent synthesis. Differing from previous reports relied on toxic cyanating agents or multistep synthesis, this mechanistically distinct protocol serves as a step-economic, regioselective and functionally tolerant strategy to obtain 5-cyano-pyrazolo[1,5-a]pyrimidines. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Filename Description adsc202201361-sup-0001-misc_information.pdf5.1 MB Supporting Information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume365, Issue6March 21, 2023Pages 871-876 This article also appears in:Hot Topic: Earth-Abundant Transition Metal Catalysis RelatedInformation