光毒性
光动力疗法
光热治疗
敏化
肿瘤微环境
化学
体内
透明质酸
生物物理学
纳米技术
光化学
癌症研究
肿瘤细胞
材料科学
医学
体外
免疫学
生物化学
有机化学
生物技术
解剖
生物
作者
Shuaipeng Feng,Xiang-Ping Yan,Junya Lu,Ziang Chen,Zhouyu Jiang,Qingqing Xu,Wanmiao Gu,Siling Wang,Qinfu Zhao
标识
DOI:10.1016/j.jcis.2024.02.160
摘要
Photodynamic therapy (PDT) is limited in tumor therapy due to the mature antioxidant barrier of tumor microenvironment (TME) and phototoxicity/easy-degradation characteristics of photosensitizers. Therefore, we prepared Cu2+-doped hollow carbon nanoparticles (CHC) to protect the loaded photosensitizers and sensitize TME by glutathione-depletion and peroxidase (POD)-like activity for enhanced PDT. CHC significantly increased the maximum speed of POD-like reaction (Vm) of 8.4 times. By coating with hyaluronic acid (HA), the active sites on CHC were temporarily masked with low catalytic property, and restored in response to the overexpressed hyaluronidase in TME. Meanwhile, due to the excellent photothermal conversion efficiency (32.5 %) and hollow structure of CHC, the loaded photosensitizers were well protected from sunlight activation-induced unwanted phototoxicity and rapid degradation under the near-infrared light irradiation. In-vivo anti-tumor experiments demonstrated that the combination of photothermal-photodynamic effect achieved the best anti-tumor effect (tumor inhibition rate at 87.8 %) compared with any monotherapy. In addition, the combination of photothermal and photodynamic effect could efficiently suppress the cell migration, manifesting the reduced number of lung metastasized nodules by 74 %. This work provides an integrated platform for photosensitizers protection and TME sensitization for enhanced PDT.
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