医学
抗磷脂综合征
灾难性抗磷脂综合征
血栓性微血管病
需要知道
疾病
重症监护医学
细胞激素风暴
多器官衰竭
儿科
内科学
血栓形成
2019年冠状病毒病(COVID-19)
计算机安全
计算机科学
传染病(医学专业)
作者
Ignasi Rodríguez‐Pintó,Gerard Espinosa,Ricard Cervera
出处
期刊:Rheumatology
[Oxford University Press]
日期:2024-02-01
卷期号:63 (SI): SI46-SI53
被引量:1
标识
DOI:10.1093/rheumatology/kead556
摘要
Catastrophic antiphospholipid syndrome (CAPS) is a severe condition with high mortality. Since its description in 1992, an important effort has been made to improve and disseminate knowledge on CAPS. Most of our current knowledge comes from the studies performed using the CAPS Registry, a database created in 2000 to gather as many cases as possible in order to better define this disease. It has demonstrated that this condition has multiple faces and is often triggered by a precipitating factor that leads to a thrombotic microangiopathy and cytokine storm involving almost any organ of the body. Analysis of the CAPS Registry has also shown that patients receiving anticoagulation, glucocorticoids and plasma exchange and/or IVIG have a better prognosis. However, there are still many unresolved questions. In this review we summarize what is known and what is still a matter of research in this condition.
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