粪便
微生物群
肠道菌群
生物
疾病
瘤胃球菌
阿尔茨海默病
内科学
免疫学
医学
微生物学
生物信息学
作者
Alba Troci,Sarah Philippen,Philipp Rausch,Julius Rave,Gina Weyland,K. Olaf Niemann,K Jessen,Lars-Patrick Andreas Schmill,Schekeb Aludin,André Franke,Daniela Berg,Corinna Bang,Thorsten Bartsch
标识
DOI:10.1093/pnasnexus/pgad427
摘要
Abstract Microbial communities in the intestinal tract are suggested to impact the ethiopathogenesis of Alzheimer’s disease (AD). The human microbiome might modulate neuroinflammatory processes and contribute to neurodegeneration in AD. However, the microbial compositions in AD patients at different stages of the disease are still not fully characterized. We used 16S rRNA analyses to investigate the oral and fecal microbiota in patients with AD and mild cognitive impairment (MCI) (n=84), at-risk individuals (APOE4 carriers) (n=17) and healthy controls (n=50) and investigated the relationship of microbial communities and disease specific markers via multivariate- and network-based approaches. We found a slightly decreased diversity in the fecal microbiota of AD patients (average Chao1 diversity for AD = 212 (SD=66); for Controls = 215 (SD=55)) and identified differences in bacterial abundances including Bacteroidetes, Ruminococcus, Sutterella, and Porphyromonadaceae. The diversity in the oral microbiota was increased in AD patients and at-risk individuals (average Chao1 diversity for AD = 174 (SD=60), for at-risk group = 195 (SD=49)). Gram-negative pro-inflammatory bacteria including Haemophilus, Neisseria, Actinobacillus and Porphyromonas were dominant oral bacteria in AD and MCI patients and the abundance correlated with the cerebrospinal fluid (CSF) biomarker. Taken together, we observed a strong shift in the fecal and the oral communities of patients with AD already prominent in prodromal and, in case of the oral microbiota, in at-risk stages. This indicates stage-dependent alterations in oral and fecal microbiota in AD which may contribute to the pathogenesis via a facilitated intestinal and systemic inflammation leading to neuroinflammation and neurodegeneration.
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