惊厥
癫痫发生
英语
神经科学
癫痫
发作性
记忆巩固
心理学
情景记忆
海马体
认知
作者
Shengjie Lai,Libo Zhang,Xing-ying Tu,Xinyue Ma,Y. Song,Kexin Cao,Miaomiao Li,Jingjing Meng,Yiqiang Shi,Qing Wu,Yang Chen,Zi-Jian Lan,C. Geoffrey Lau,Jie Shi,Weining Ma,Shaoyi Li,Yanxue Xue,Zhuo Huang
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2024-03-22
卷期号:10 (12)
标识
DOI:10.1126/sciadv.adk9484
摘要
Epileptogenesis, arising from alterations in synaptic strength, shares mechanistic and phenotypic parallels with memory formation. However, direct evidence supporting the existence of seizure memory remains scarce. Leveraging a conditioned seizure memory (CSM) paradigm, we found that CSM enabled the environmental cue to trigger seizure repetitively, and activating cue-responding engram cells could generate CSM artificially. Moreover, cue exposure initiated an analogous process of memory reconsolidation driven by mammalian target of rapamycin–brain-derived neurotrophic factor signaling. Pharmacological targeting of the mammalian target of rapamycin pathway within a limited time window reduced seizures in animals and interictal epileptiform discharges in patients with refractory seizures. Our findings reveal a causal link between seizure memory engrams and seizures, which leads us to a deeper understanding of epileptogenesis and points to a promising direction for epilepsy treatment.
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