发病机制
生物
疾病
炎症
免疫学
生物信息学
病理
医学
作者
Raúl F. Reyes-Huerta,Vladimir Mandujano-López,Guadalupe Velásquez-Ortiz,Beatriz Alcalá-Carmona,María J Ostos-Prado,Yatzil Reyna-Juárez,David Eduardo Meza-Sánchez,Guillermo Juárez‐Vega,Nancy R. Mejía‐Domínguez,Jiram Torres-Ruíz,Diana Gómez‐Martín,José Luis Maravillas-Montero
标识
DOI:10.1093/jleuko/qiae083
摘要
Abstract Idiopathic inflammatory myopathies are a heterogeneous group of rare autoimmune disorders characterized by progressive muscle weakness and the histopathologic findings of inflammatory infiltrates in muscle tissue. Although their pathogenesis remains indefinite, the association of autoantibodies with clinical manifestations and the evidence of high effectiveness of depleting therapies suggest that B cells could be implicated. Therefore, we explored the landscape of peripheral B cells in this disease by multiparametric flow cytometry, finding significant numerical decreases in memory and double negative subsets, as well as an expansion of the naïve compartment relative to healthy controls, that contribute to defining disease-associated B cell subset signatures and correlating with different clinical features of patients. Additionally, we determined the potential value of these subsets as diagnostic biomarkers, thus positioning B cells as neglected key elements possibly participating in idiopathic inflammatory myopathies onset or development.
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