检出限
荧光
同型半胱氨酸
化学
量子点
掺杂剂
碳纤维
柠檬酸
核化学
无机化学
兴奋剂
材料科学
色谱法
纳米技术
生物化学
光电子学
复合数
物理
量子力学
复合材料
作者
Anju S. Madanan,Ajayakumar Aswathy,Susan Varghese,Merin K. Abraham,R S Lekshmi,Ali Ibrahim Shkhair,G M Lekha,Sasidharanpillai S. Syamchand,Sony George
出处
期刊:Luminescence
[Wiley]
日期:2022-12-05
卷期号:38 (1): 19-27
被引量:1
摘要
This study describes the development of a low-cost fluorescence assay for detecting homocysteine (Hcy) without the interference of cysteine and glutathione using carbon quantum dots. Herein nitrogen-doped carbon quantum dots (NCDs) were synthesized from citric acid as the carbon source and urea as the dopant using a one-pot microwave-assisted method. The obtained NCDs were incorporated with folic acid (FA) by the direct ex situ addition method and were used as a fluorescence probe to detect Hcy. The probe exhibited a fluorescence turn-on response with increased Hcy concentration up to 50 μM with a limit of detection of 2.276 μM. The point of care detection of Hcy using the probe was also tested with a paper-based assay strip.
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