Recent Developments in Cyclopropane Cycloaddition Reactions

In organic synthesis, the synthetic methodology of using cyclopropanes for cycloadditions has witnessed significant progress over the past several years. A series of cyclopropane-related cycloaddition reactions via organic or metal-catalyzed/mediated pathways has been exploited in constructing cyclic frameworks such as polycycles, bridged-ring carbocycles, and heterocycles. Moreover, this synthetic chemistry has also recently blossomed in the pursuit of highly efficient asymmetric cycloadditions, C–H bond-activated cycloadditions, photoredox catalysis-cooperated cycloadditions, and several other unique reaction processes. Although numerous cyclopropane-based cycloaddition reactions have been reported, the newly explored cycloadditions have not yet been reviewed. Herein, we present recent progress in cyclopropane-related cycloadditions over the past 6 years.