傅里叶变换红外光谱
铁质
核化学
模拟体液
聚乙二醇
药物输送
混合材料
紫外可见光谱
材料科学
光谱学
化学
化学工程
纳米技术
有机化学
冶金
扫描电子显微镜
复合材料
工程类
物理
量子力学
作者
Michelina Catauro,Elisabetta Tranquillo,Federico Barrino,Ignazio Blanco,Francesco Dal Poggetto,Daniele Naviglio
出处
期刊:Materials
[MDPI AG]
日期:2018-11-14
卷期号:11 (11): 2270-2270
被引量:37
摘要
The use of oral iron integration is commonly recommended for the treatment of iron deficiency, nevertheless the diagnosis and treatment of this disease could clearly be improved. The aim of this work was the synthesis of therapeutic systems, iron (II) based, by sol-gel method. In an SiO₂ matrix, we embedded different weight percentages of polyethylene glycol (PEG6, 12, 24 wt%) and ferrous citrate (Fe(II)C5, 10, 15 wt%) for drug delivery applications. Fourier Transform Infrared (FTIR) spectroscopy was used to study the interactions among different components in the hybrid materials. Release kinetics in a simulated body fluid (SBF) were investigated and the amount of Fe2+ released was detected by Ultraviolet⁻Visible spectroscopy (UV-VIS) after reaction with ortho-phenantroline. Furthermore, the biological characterization was carried out. The bioactivity of the synthesized hybrid materials was evaluated by the formation of a layer of hydroxyapatite on the surface of samples soaked in SBF using FTIR spectroscopy. Finally, also, the potential antibacterial properties of the different materials against two different bacteria, E. coli and P. aeruginosa, were investigated.
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