结合
荧光
香豆素
硼酸
化学
配体(生物化学)
氨基酸
产量(工程)
组合化学
硼
生物物理学
立体化学
受体
材料科学
生物化学
有机化学
生物
数学
物理
数学分析
冶金
量子力学
作者
Ricardo Lopes,Ana E. Ventura,Liana C. Silva,Hélio Faustino,Pedro M. P. Góis
标识
DOI:10.1002/chem.201802515
摘要
Herein a new class of iminoboronates obtained from 2-acetylbenzene boronic acids and aminophenols is presented. The N,O-ligand topology enabled the formation of an additional B-O bond that locks the boron center in a tetrahedral geometry. This molecular arrangement decisively contributes to improve the construct's stability in biocompatible conditions and retaining the iminoboronate reversibility in more acidic environments. 2-Acetylbenzene boronic acid was reacted with a fluorescent amino-coumarin to yield a stable and non-fluorescent N,O-iminoboronate. This mechanism was further used to assemble a folate receptor targeting conjugate that selectively delivered the fluorescent amino-coumarin to MDA-MB-231 human breast cancer cells.
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