生物素化
姜黄素
化学
丙酮
细胞毒性T细胞
肽
共价键
生物化学
细胞生物学
组合化学
生物
体外
有机化学
作者
Hiroyuki Yamakoshi,Naoki Kanoh,Chiaki Kudo,Atsuko Sato,Kazunori Ueda,Makoto Muroi,Shunsuke Kon,Masanobu Satake,Hisatsugu Ohori,Chikashi Ishioka,Yoshiteru Oshima,Hiroyuki Osada,Natsuko Chiba,Hiroyuki Shibata,Yoshiharu Iwabuchi
摘要
Bis(arylmethylidene)acetone derivatives are an important class of curcumin analogues that exhibit various biological and pharmacological activities.We herein report that GO-Y086, a biotinylated bis(arylmethylidene)acetone, inhibits cancer cell growth.We also show that GO-Y086 specifically interacts with the nuclear protein KSRP/FUBP2 by covalent modification.GO-Y086 markedly suppresses the expression of the c-Myc protein, which plays an important role in cellular proliferation and whose expression is regulated by KSRP/FUBP2.
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