品味
受体
味觉感受器
感觉系统
神经科学
感觉受体
多克隆抗体
舌乳头
生物
内科学
内分泌学
解剖
细胞生物学
化学
抗体
医学
免疫学
作者
Xuenong Bo,Atossa Alavi,Zhenghua Xiang,Ian B Oglesby,Anthony Ford,Geoffrey Burnstock
出处
期刊:Neuroreport
[Ovid Technologies (Wolters Kluwer)]
日期:1999-04-01
卷期号:10 (5): 1107-1111
被引量:152
标识
DOI:10.1097/00001756-199904060-00037
摘要
P2X receptors have been suggested to play a role in the transduction of sensory signals such as pain and sound. In the present study, polyclonal antibodies against P2X1 to P2X6 receptors were used to localize P2X receptors in circumvallate and fungiform papillae of rats. Nerve fibres innervating the taste buds stained intensely with P2X3 receptor antibodies. P2X3 receptor-positive nerves were observed in the intra- and subgemmal regions. The nerve fibres were also stained with P2X2 receptor antibodies, but the intensity was much lower. The distribution of P2X2 receptor immunoreactivity overlaps with that of P2X3. These results suggest that ATP might be a neurotransmitter in taste reception cells in the taste buds, where it transducts the taste signals to the afferent taste nerves by activating P2X receptors at the synapses. This is the first experiment indicating such a role for ATP, although supplementary functional studies are required.
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