受体
信号转导
化学
细胞生物学
FKBP公司
细胞质
顺反异构体
生物
计算生物学
生物化学
肽基脯氨酰异构酶
酶
异构酶
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1991-01-18
卷期号:251 (4991): 283-287
被引量:1426
标识
DOI:10.1126/science.1702904
摘要
Cyclosporin A, FK506, and rapamycin are inhibitors of specific signal transduction pathways that lead to T lymphocyte activation. These immunosuppressive agents bind with high affinity to cytoplasmic receptors termed immunophilins (immunosuppressant binding proteins). Studies in this area have focused on the structural basis for the molecular recognition of immunosuppressants by immunophilins and the biological consequences of their interactions. Defining the biological roles of this emerging family of receptors and their ligands may illuminate the process of protein trafficking in cells and the mechanisms of signal transmission through the cytoplasm.
科研通智能强力驱动
Strongly Powered by AbleSci AI