神经科学
双相情感障碍
奶油
神经可塑性
心理学
氯氮平
抗精神病药
精神分裂症(面向对象编程)
突触可塑性
神经营养因子
心情
情绪障碍
精神科
医学
转录因子
认知
生物
内科学
受体
焦虑
基因
生物化学
标识
DOI:10.1038/sj.mp.4001016
摘要
Recent studies demonstrate that the molecular elements known to regulate neuronal plasticity in models of learning and memory are also involved in the actions of drugs used for the treatment of depression and bipolar disorder. This includes up-regulation of transcription factors, such as the cAMP response element binding protein and neurotrophic factors, such as brain derived neurotrophic factor. These findings raise the possibility that regulation of neural plasticity in specific neuronal circuits is integrally involved in the therapeutic intervention of mood disorders. Atypical antipsychotic drugs, including clozapine and olanzapine, are also effective for the treatment of bipolar disorder, and are used as add-on medication for unipolar depression. The possibility that these atypical antipsychotic drugs also influence the molecular determinants of synaptic plasticity that are involved in the response to drugs used for the treatment of mood disorders, is discussed.
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