羊膜穿刺术
家族性地中海热
秋水仙碱
医学
产科
妊娠期
怀孕
遗传咨询
唐氏综合症
产前诊断
妇科
遗传学
胎儿
病理
内科学
生物
疾病
精神科
作者
Michal Berkenstadt,Boaz Weisz,Howard Cuckle,Michal Di-Castro,Esther Guetta,Gad Barkai
标识
DOI:10.1016/j.ajog.2005.03.043
摘要
To determine whether colchicine prescribed for familial Mediterranean fever is teratogenic.Reproductive histories were analyzed from 326 couples referred for prenatal diagnosis because 1 partner was affected. Numbers of chromosomal abnormalities and birth defects were compared with numbers expected from published rates.There were 901 pregnancies, and amniocentesis had been performed in 566, all but 3 conceived while taking colchicine. Seven numerical chromosomal abnormalities were found, not statistically significantly greater than the 4.99 expected from maternal age and gestation of diagnosis (P = .24): unbalanced structural abnormalities were 6, compared with 3.22 expected (P = .11). There were 7 birth defects, a considerably lower rate than reported in local malformation registers.The current policy of routine amniocentesis in pregnancies of couples taking colchicine should not be changed until sufficient data accumulates to establish whether the higher number of chromosomal anomalies in this group is significant.
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