Dialkylation of 1,3-Dienes by Dual Photoredox and Chromium Catalysis

The direct conversion of feedstock chemicals into value-added products is of broad interest in chemical research. Herein, we present a regioselective and diastereoselective three-component dialkylation of feedstock 1,3-dienes with Hantzsch esters and aldehydes for the synthesis of homoallylic alcohols. The reaction is enabled by dual photoredox and chromium catalysis and can also be performed enantioselectively by employing chromium-bisoxazoline complexes.