Non-motor symptoms in Parkinson′s disease patients with different motor types

One hundred ten patients with Parkinson′s disease (PD) and 110 age-matched healthy controls were enrolled in the study. The non-motor symptoms (NMS) were assessed with Non-motor symptoms of Parkinson′s disease questionnaire (PDNMSQ30). The PD patients were classified as gait abnormality posture type (PIGD, n=73) and tremor type (TD, n=37). The non-motor symptoms were compared between two groups. Results showed that the NMS in PD patients was higher than that in healthy controls[(35.2±3.0) vs. (6.0±2.0) symptoms, t=6.43, P=0.01]. The NMS score of PIGD group was higher than that of TD group[(28.9±1.1)vs.(6.2±0.7)symptoms, t=2.73, P<0.01]; Mini-mental state examination (MMSE) and Montreal cognitive assessment scale (MoCA) scores of TD group were significantly higher than those of PIGD group(t=11.52, P<0.01; t=8.79, P<0.01). The results indicate that for PD patients with different motor types, their NMS are different, and PD patients with PIGD have more axial involvement, and more NMS. Key words: Parkinsons disease; Motor types; Non-motor symptom; Hoehn-Yahr classification; Tremor dominant